Hydroxychloroquine alleviates cyclophosphamide-induced premature ovarian failure by attenuating granulosa cell senescence and modulating the mtDNA-cGAS pathway - PubMed
4 hours ago
- #Premature Ovarian Failure
- #Granulosa Cell Senescence
- #Hydroxychloroquine
- Hydroxychloroquine (HCQ) mitigates cyclophosphamide (CTX)-induced premature ovarian failure (POF) in mice.
- HCQ reduces granulosa cell senescence, stabilizes mitochondrial membranes, and decreases ROS production.
- The study highlights HCQ's role in modulating the mtDNA-cGAS-STING signaling pathway to prevent ovarian damage.
- In vitro tests on human ovarian granulosa cells (KGN) confirm HCQ's protective effects against CTX-induced damage.
- HCQ improves ovarian function, reduces follicular depletion, and enhances reproductive outcomes in CTX-treated models.