YAP Induces a Prorenewal Metabolic State in Cardiomyocytes - PubMed
3 days ago
- #metabolic remodeling
- #cardiac regeneration
- #YAP
- YAP promotes cardiac regenerative repair by inducing a neonatal-like metabolic state in mature cardiomyocytes.
- YAP reduces fatty acid utilization in cardiomyocytes, promoting fatty acid anabolism and phospholipid biosynthesis.
- YAP inhibits the cardiac maturation transcription factor MEF2A, decreasing gene expression related to cardiomyocyte maturity pathways.
- Perturbing MEF2A transcriptional activity can interrupt the cardiomyocyte maturation program and restore heart regenerative capacity.
- The study provides insights into therapeutic interventions for heart failure by balancing cardiomyocyte metabolic maturation and proliferation.