Biodegradable targeted polymeric mRNA nanoparticles enable in vivo CD19 CAR T cell generation and lead to B cell depletion - PubMed
12 hours ago
- #B cell depletion
- #mRNA nanoparticles
- #CAR T cells
- Biodegradable polymeric mRNA nanoparticles enable in vivo generation of CD19 CAR T cells.
- Targeted nanoparticles with T cell-activating ligands improve transfection and selectivity in vivo.
- In vivo delivery of anti-CD19 CAR mRNA led to significant B cell depletion in mice.
- The technology offers a nonviral, streamlined alternative to current CAR T cell therapies.
- Johns Hopkins has filed a patent related to this technology, with several authors as coinventors.
- Some authors have competing interests, including consulting roles and equity in biotech companies.