Health effects of PFASs on five major human cancers: A network toxicology perspective on molecular pathogenesis - PubMed
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- PFASs, including PFOA and PFOS, are linked to increased risks of five major human cancers: gastric, colorectal, liver, kidney, and breast cancer.
- PFOS affects 24 pathways, with 9 common across different cancers, notably the Ribosome pathway in rectal, liver, and kidney cancers.
- PFOA impacts 32 pathways, with 10 shared among cancers, especially the PPAR signaling pathway in all five major cancers.
- PFOA primarily induces cancer via the PPAR pathway, while PFOS disrupts reactive oxygen species and ribosomes.
- Despite similar structures, PFOA and PFOS exhibit distinct carcinogenic mechanisms.
- The study provides a foundation for health assessments and identifying potential pathways in PFAS-induced cancer.