Therapeutic potential of Qihuang Biwen Formula and its bioactive compounds for the treatment of ulcerative colitis in Drosophila and mice - PubMed
4 hours ago
- #ulcerative-colitis
- #Qihuang-Biwen-Formula
- #TLR4-NF-κB-pathway
- Qihuang Biwen Formula (QHBWF) is derived from Yupingfeng Powder and traditionally used for immune regulation.
- The study investigated QHBWF's effectiveness in treating ulcerative colitis (UC) using Drosophila and mice models.
- QHBWF improved survival rates, locomotor activity, and intestinal function in DSS-induced UC models.
- It restored intestinal morphology, reduced intestinal epithelial cell apoptosis, and suppressed aberrant intestinal stem cell proliferation.
- In mice, QHBWF alleviated weight loss, colon shortening, and improved histopathology while reducing IL-6, IL-1β, and ROS levels.
- Mechanistically, QHBWF down-regulated Toll and Imd signaling pathways and up-regulated mitochondrial oxidative phosphorylation (OXPHOS).
- Key bioactive compounds identified include kaempferol, emodin, quercetin, isochlorogenic acid, and chlorogenic acid.
- QHBWF targets the TLR4/NF-κB signaling pathway and enhances OXPHOS function to exert anti-colitis effects.