Extent of Tau and Its Cognitive Implications in Patients With Cerebral Amyloid Angiopathy Without Cognitive Impairment - PubMed
4 hours ago
- #Cognitive Impairment
- #Cerebral Amyloid Angiopathy
- #Tau Pathology
- Study examines tau pathology in patients with cerebral amyloid angiopathy (CAA) without cognitive impairment.
- Tau extent, measured via PET-Braak staging, was more frequent in CAA patients compared to healthy controls.
- Later PET-Braak stages were associated with age and amyloid burden, but not with CAA diagnosis or CAA-specific markers.
- Within CAA patients, tau extent did not correlate with CAA-related imaging markers or cognitive function scores.
- Findings suggest tau pathology in CAA is driven by age and amyloid, not directly affecting CAA disease mechanisms or cognition in non-impaired patients.