Early-Onset Thiazide-Induced Hyponatremia Leading to Seizure in a Middle-Aged Woman Using Aldactazide - PubMed
3 hours ago
- #thiazide-diuretics
- #seizure
- #hyponatremia
- Thiazide-induced hyponatremia (TIH) is a known adverse effect of thiazide diuretics, typically seen in elderly individuals.
- A 52-year-old woman developed severe hyponatremia (115 mmol/L) and a generalized seizure shortly after starting Aldactazide (spironolactone + hydrochlorothiazide).
- Laboratory findings included hypokalemia (3.3 mmol/L) and hypochloremia (76 mmol/L), with normal renal, thyroid, and adrenal functions.
- Brain imaging showed no acute abnormalities, and controlled correction with hypertonic saline normalized sodium levels without overcorrection.
- The case highlights that TIH can develop rapidly in middle-aged individuals, leading to severe neurological complications like seizures.
- Clinicians should monitor serum sodium closely during early thiazide therapy, especially with combination regimens like Aldactazide.