TREM2 as a possible link between Alzheimer's disease and diabetes mellitus - PubMed

3 hours ago

Alzheimer's disease (AD) and diabetes mellitus (DM) are strongly associated, with diabetic patients at higher risk of AD.
Chronic low-grade inflammation is a central mechanism linking AD and DM.
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a critical role in both AD and DM.
In AD, TREM2 is expressed on microglia, influencing neuroinflammation, amyloid-β (Aβ), and Tau pathology.
In DM, TREM2 contributes to insulin resistance and metabolic dysregulation.
Genetic variants of TREM2 are risk factors for AD, while altered TREM2 expression correlates with DM pathology.
TREM2 may serve as a therapeutic target for both diseases.
Understanding TREM2-mediated mechanisms could provide insights into AD-DM interplay and inform precision therapies.

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