Accuracy of muscle ultrasonography in detecting fasciculations for the diagnosis of amyotrophic lateral sclerosis: a systematic review and meta-analysis - PubMed
5 hours ago
- #ALS Diagnosis
- #Systematic Review
- #Muscle Ultrasonography
- This systematic review and meta-analysis evaluated muscle ultrasonography for detecting fasciculations in amyotrophic lateral sclerosis (ALS) diagnosis.
- It analyzed 13 studies with 1176 participants, finding pooled sensitivity of 0.87, specificity of 0.91, and an area under the SROC curve of 0.94.
- Scan duration significantly affected accuracy, with ≥30 seconds improving sensitivity but reducing specificity; no significant publication bias was detected.
- The method showed good diagnostic accuracy, potentially serving as a useful adjunct to electrodiagnostic evaluation in ALS diagnosis.