Brain endothelial PTPRO drives LPS-induced metabolic reprogramming and neuroinflammation in sepsis-associated encephalopathy - PubMed
8 hours ago
- #Blood-brain barrier
- #Sepsis-associated encephalopathy
- #PTPRO
- Brain endothelial protein tyrosine phosphatase receptor type O (PTPRO) drives lipopolysaccharide (LPS)-induced metabolic reprogramming and neuroinflammation in sepsis-associated encephalopathy (SAE).
- The study highlights the roles of glycolysis and hypoxia-inducible factor-1α (HIF-1α) in this process, linking PTPRO to blood-brain barrier dysfunction.
- Animal experiments were approved by the Institutional Ethical Guidelines of Bengbu Medical University of Chinese Medicine, with no competing interests declared.
- The research was supported by multiple grants from the National Natural Science Foundation of China and other provincial and university programs.