[Psychotropic drug-induced obesity in older adults: complications, preventive and therapeutic interventions] - PubMed
3 hours ago
- #psychotropic drugs
- #older adults
- #obesity
- Psychotropic drugs like olanzapine, clozapine, quetiapine, mirtazapine, valproate, and lithium can cause significant weight gain in older adults.
- Obesity in older adults increases the risk of diabetes, cardiovascular diseases, malignancies, sarcopenic obesity, and frailty.
- Preventive measures include using drugs with lower metabolic risk (e.g., aripiprazole, venlafaxine, lamotrigine), regular monitoring, and lifestyle interventions.
- Therapeutic options include switching medications, intensive lifestyle programs, metformin, or GLP1 agonists.
- For younger-old adults (65-74 years), weight reduction is a primary goal, while for the oldest-old (≥75 years), preserving functional capacity is paramount.