Deconstruction of a memory engram reveals distinct ensembles recruited at learning - PubMed
a day ago
- #fear conditioning
- #memory
- #neuroscience
- The study investigates associative memory formation by identifying distinct neuronal ensembles in dorsal CA1 active during fear memory acquisition.
- Calcium influx visualization and tagging techniques were used with high temporal precision to track cell activity.
- Nonoverlapping neuronal ensembles were found to be differentially active during different periods of associative fear memory acquisition.
- Cells associated with specific acquisition periods alone can drive memory expression and contribute to fear engram formation.
- The research delineates which cell ensembles form the core engram essential for memory formation and recall.
- Funding sources include the Brain & Behavior Research Foundation, French National Research Agency, Burroughs Wellcome Fund, and Foundation for the National Institutes of Health.