Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcome - PubMed
3 days ago
- #biomarkers
- #tumor microenvironment
- #oral cancer
- Spatial single-cell analysis identifies tumor microenvironment signatures in oral cavity cancer.
- Presence of proliferating lymphatic endothelial cells (KI67+PROX1+) at the tumor margin predicts poor recurrence-free survival in early-stage OSCC.
- Findings validated in an independent cohort using a KI67+PROX1+ immunostaining biomarker assay.
- Study highlights the role of the tumor microenvironment in OSCC progression and potential treatment strategies.
- Patent application filed based on this work, with some authors having ties to a biotech company.