Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy - PubMed
3 days ago
- #Piezo1 channel
- #chemotherapy
- #bladder cancer
- Intravesical chemotherapy for bladder cancer has poor efficacy and significant toxicity.
- Programmable mechanical pressure enhances chemotherapy by activating Piezo1 channels in bladder cancer.
- Piezo1 activation triggers a calcium ion cascade, increasing mechanosensitivity and membrane permeability.
- This mechano-chemotherapy enhances intracellular accumulation of drugs like Doxorubicin and Mitomycin-C.
- Mechano-chemotherapy increases tumor cell apoptosis and reduces mucosal toxicity in orthotopic models.
- The strategy transforms mechanical force into a safe and effective tool for cancer treatment.