Fitness Training for γδ T cells in mouse and human atherosclerosis takes place in plaques and artery tertiary lymphoid organs - PubMed
4 hours ago
- #immune education
- #γδ T cells
- #atherosclerosis
- γδ T cells are rare in the cardiovascular system but play a role in atherosclerosis.
- Study used scRNA-seq, scTCR-seq, and spatial transcriptomics to analyze γδ T cells in mouse and human atherosclerosis.
- γδ T17 cells were found enriched in atherosclerotic plaques and artery tertiary lymphoid organs (ATLOs).
- Clonal expansion of γδ T17 cells with identical TCR chains was observed in plaques and ATLOs.
- Plaques and ATLOs educate γδ T17 cells towards an anti-apoptotic, tissue-resident phenotype.
- γδ T17 cells undergo metabolic reprogramming in the atherosclerotic microenvironment.
- Human plaques have fewer γδ T cells, dominated by effector/cytolytic subtypes.
- Findings highlight species-specific roles of γδ T cells in atherosclerosis.