Associations of cumulative exposure and dynamic trajectories of the triglyceride-total cholesterol-body weight index with new-onset cardiometabolic multimorbidity in middle-aged and older Chinese adul
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- #Triglyceride-Cholesterol Index
- #Cohort Study
- #Cardiometabolic Multimorbidity
- Study investigates triglyceride-total cholesterol-body weight index (TCBI) associations with cardiometabolic multimorbidity (CMM) in Chinese middle-aged and older adults.
- Higher cumulative TCBI exposure linked to 18% increased CMM risk per 1-SD increase; highest tertile had 1.9 times higher risk compared to lowest.
- Three TCBI trajectories identified (low-stable, moderate-stable, high-stable); high-stable group had 61% greater CMM risk than low-stable group.
- Associations remained consistent across subgroups and robust in sensitivity analyses, satisfying proportional hazards assumptions.
- TCBI provided incremental predictive value beyond individual components (NRI = 0.158, P < 0.001), supporting its utility in risk assessment.
- A Cox-based nomogram prediction model developed, showing acceptable discrimination (AUC: 0.715 training, 0.694 validation) and favorable clinical net benefit.
- Findings suggest TCBI as a practical tool for early risk stratification and personalized management of cardiometabolic multimorbidity.