PD-1 blockade promotes mucosal CD4+ T cell IL-10 production through altering microbiota to reduce intestinal ischemia reperfusion injury - PubMed
5 days ago
- #IL-10
- #gut microbiota
- #PD-1 blockade
- PD-1 blockade activates intestinal IgA responses via a MyD88-dependent pathway in mice.
- PD-1 blockade reshapes gut microbial composition and metabolite profile, increasing butyrate-producing bacteria like Lachnospiraceae_NK4A136_group.
- Increased microbiota-derived butyrate correlates with enhanced IL-10 production in intestinal mucosa.
- IL-10 upregulation suppresses inflammatory activation, improving gut barrier function and reducing remote organ injury from intestinal ischemia reperfusion (IR).
- Butyrate supplementation enhances IL-10 expression in CD4+ T cells through PI3Kγ/phospho-mTOR signaling.