Disruption of primary ciliary prostaglandin E2 signaling by transforming growth factor-β1 impairs endometrial receptivity - PubMed
7 hours ago
- #Endometrial Receptivity
- #Primary Cilia
- #TGF-β1
- Primary cilia in endometrial stromal cells (ESCs) are crucial for decidualization and uterine receptivity.
- Prostaglandin E2 (PGE2) binding to the EP4 receptor on primary cilia stimulates decidualization, enhanced by 17β-estradiol and progesterone.
- Transforming growth factor-β1 (TGF-β1) inhibits ciliogenesis and PGE2-EP4 signaling, impairing decidualization and endometrial receptivity.
- TGF-β1 suppresses chicken ovalbumin upstream promoter transcription factor II and kinesin family member 3B, leading to reduced ciliogenesis.
- In mice, TGF-β1 administration impaired implantation, while TGF-β receptor blockade restored fertility.
- Women with endometriosis and failed IVF-ET showed shorter cilia and reduced decidual response due to elevated TGF-β1.
- Cilia length and ciliation frequency are potential biomarkers for endometrial receptivity, with predictive value for reproductive outcomes.
- Targeting TGF-β signaling may restore ciliated cell number and ciliary length, improving fertility outcomes.