Transcutaneous spinal cord stimulation plus locomotor training versus sham-stimulation plus locomotor training in chronic spinal cord injury (eWALK): a multicentre, triple-blind, randomised, sham-cont

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Study compared transcutaneous spinal cord stimulation (tSCS) plus locomotor training vs. sham-stimulation plus locomotor training in chronic spinal cord injury (SCI) patients.
50 participants with chronic SCI and limited walking ability were randomly assigned to either stimulation or sham groups.
Primary outcome was walking ability (WISCI-II) at 12 weeks, with no significant difference found between groups.
Both groups showed improvements in walking ability, maintained at 16 weeks, but tSCS did not provide additional benefits over locomotor training alone.
Adverse events were similar across groups, with no serious adverse events reported.
Future research suggested to explore tSCS effects in diverse SCI populations and different training combinations.

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