Faecalibacterium prausnitzii enzyme reprograms PD-L1 trafficking and sensitizes colorectal cancer to immunotherapy in mice - PubMed
3 hours ago
- #colorectal cancer
- #immunotherapy
- #microbiome
- Faecalibacterium prausnitzii abundance correlates with improved colorectal cancer survival and immunotherapy response.
- The enzyme fpPRPS from F. prausnitzii inhibits tumor development and enhances CD8+ T-cell responses by disrupting PD-L1 trafficking.
- fpPRPS depletes ATP in cancer cells, leading to Rab11a degradation and reduced PD-L1-mediated T-cell inhibition.
- Combining fpPRPS with anti-PD-1 therapy synergistically promotes tumor control in mouse models.
- Findings suggest fpPRPS as a potential strategy to sensitize colorectal cancer to immunotherapy.