Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming - PubMed
7 hours ago
- #small cell lung cancer
- #perineural invasion
- #metabolic reprogramming
- Perineural invasion (PNI) is an independent adverse prognostic factor in small cell lung cancer (SCLC).
- The neural microenvironment upregulates stathmin-2 (STMN2) in SCLC cells, which activates the β-alanine metabolic pathway.
- Intracellular β-alanine accumulation, driven by STMN2, enhances SCLC cell migration and invasion.
- STMN2 knockdown suppresses neural invasion in vivo, an effect reversible by β-alanine supplementation.
- The study identifies a neural-STMN2-β-alanine-invasion axis driving PNI in SCLC, highlighting a metabolic vulnerability for therapy.