Injectable dual-drug hydrogel containing curcumin and glycyrrhizic acid for biofilm inhibition and immunomodulatory therapy in periodontitis - PubMed
4 hours ago
- #immunomodulation
- #hydrogel
- #periodontitis
- Injectable dual-drug hydrogel (CURM@GLH) developed for periodontitis treatment, combining curcumin (CUR) and glycyrrhizic acid (GL).
- CUR micelles (CURM) show improved solubility, stability, and enhanced antioxidative, anti-inflammatory, and antibacterial properties.
- GL hydrogel (GLH) provides intrinsic anti-inflammatory and antioxidative effects, aiding immune regulation.
- CURM@GLH reduces oxidative stress, promotes macrophage polarization to M2 phenotype, and downregulates proinflammatory cytokines.
- In vivo studies show significant alleviation of periodontal oxidative stress, inflammation, and alveolar bone resorption.
- The hydrogel offers a host-directed therapeutic strategy targeting both biofilm inhibition and immunomodulation.