Trimbody with rigid AI-designed scaffolds enables atomic-resolution cryo-EM structure determination of small proteins - PubMed
4 hours ago
- #cryo-EM
- #protein-structure
- #AI-design
- Trimbody method uses AI-designed scaffolds to enable high-resolution cryo-EM of small proteins.
- Comprises a trimeric scaffold (H3-PrAC-5350A) and a nanobody fusion (Nb-TAIL) for stability and rigidity.
- Resolved atomic structures of four sub-50 kDa proteins, demonstrating versatility.
- Simple, cost-effective, and compatible with standard cryo-EM workflows.
- Potential to advance nanobody-based drug development and structural biology research.