The HIF-1α Pathway Regulates Satellite Cell Fate During Aging Through Histone Lactylation - PubMed
7 days ago
- #sarcopenia
- #satellite cells
- #HIF-1α
- Aging-associated sarcopenia is linked to the loss of type II glycolytic fibers and decline in satellite cells (SCs).
- HIF-1α signaling pathway attenuation in aged SCs can be reversed by pharmacological reactivation (e.g., roxadustat).
- HIF-1α activation in aged SCs restores glycolytic enzymes, increases lactate levels, and enhances histone lactylation.
- Increased histone lactylation is linked to chromatin remodeling and rejuvenation of aged SCs.
- HIF-1α activation shifts SCs from senescence to a quiescent, regenerative state, improving myogenic performance.
- Roxadustat treatment enhances differentiation of aged SCs, leading to hypertrophic myotubes and increased ATP content.
- The study suggests repurposing roxadustat to alleviate sarcopenia via the HIF-1α-lactate-lactylation axis.