Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis - PubMed
3 hours ago
- #colorectal cancer metastasis
- #Streptococcus salivarius
- #neutrophil extracellular traps
- Oral bacterium Streptococcus salivarius promotes colorectal cancer (CRC) metastasis by inducing neutrophil extracellular trap (NET) formation.
- S. salivarius induces formation of an IRGM1-IQGAP1 complex in neutrophils, activating Wnt5a signaling and the PI3K/AKT pathway, leading to NET formation.
- Conditional deletion of IRGM1 or pharmacological inhibition of downstream signaling with XAV-939 attenuates S. salivarius-induced NET formation.
- Clinical samples show S. salivarius is enriched in the tongue coating and feces of CRC patients and elevated within the tumor microenvironment.
- IRGM1-IQGAP1-mediated Wnt5a-PI3K/AKT signaling links oral microbiota to neutrophil-driven immune responses in cancer metastasis.