Risk assessment of secondary primary malignancies: results from two large prospective European cohorts - PubMed
7 hours ago
- #Cancer Survivorship
- #Secondary Primary Malignancies
- #Mendelian Randomization
- Study uses Mendelian randomization to assess causal links between primary cancers and secondary primary malignancies (SPMs) using data from UK Biobank and FinnGen cohorts.
- Meta-analysis finds gastric cancer significantly increases risk of secondary esophageal cancer (OR=1.29) and rectal cancer (OR=1.13), with both associations statistically significant (P<0.001).
- Single-cell sequencing identifies PLK1+ cancer stem cells as potential drivers of the causal relationship between gastric cancer and specific SPMs.
- Results provide genetic evidence to inform optimized follow-up strategies for gastric cancer survivors.