Ammonia measurement in cirrhosis: International Delphi consensus recommendations from ISHEN - PubMed
4 hours ago
- #Cirrhosis
- #Ammonia
- #Hepatic Encephalopathy
- Ammonia is a neurotoxin linked to hepatic encephalopathy (HE) in cirrhosis patients.
- The International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) developed consensus recommendations on ammonia measurement in cirrhosis.
- A modified Delphi process involved 11 experts and 39 panelists, achieving ≥90% consensus on all questions.
- Key recommendations cover ammonia's role in diagnosis, monitoring, and treatment of cirrhosis patients.
- Best practices for sample collection, analysis, and clinical interpretation of ammonia levels were established.
- Research gaps identified include the need for point-of-care testing and validation of ammonia-based risk models.
- The consensus aims to standardize ammonia measurement practices globally to improve patient outcomes and research.