RNF128 aggravates metabolic dysfunction-associated steatotic liver disease progression via stabilization of SCD1 - PubMed
7 hours ago
- #MASLD
- #SCD1
- #RNF128
- RNF128 is upregulated in MASLD livers in humans and mice.
- Hepatocyte-specific RNF128 knockout reduces MASLD, while overexpression worsens it.
- RNF128 stabilizes SCD1 via K63-linked ubiquitination at lysine 30, preventing its degradation and promoting lipid accumulation.
- SCD1 overexpression reverses the effects of RNF128 loss; SCD1 inhibition rescues RNF128-driven steatosis.
- Therapeutic inhibition of RNF128 with GalNAc-ASO and shRNA-AAV alleviates MASLD in mice.