Menstrual blood-derived mesenchymal stromal cell extracellular vesicles stimulate chondrocytes and cartilage extracellular matrix synthesis in vitro - PubMed
3 hours ago
- #extracellular vesicles
- #cartilage repair
- #osteoarthritis
- Menstrual blood-derived mesenchymal stromal cell extracellular vesicles (MenSC-EVs) stimulate chondrocyte extracellular matrix synthesis, including increased collagen type II and TGF-β3 receptor gene expression.
- MenSC-EVs reduce cartilage degradation markers (COMP and GAGs) under inflammatory conditions and support cartilage repair without significantly affecting inflammatory cytokine secretion, except for IL-6.
- Infrared absorption spectroscopy confirms enhanced collagen II and proteoglycan content in MenSC-EV treated cartilage explants, indicating extracellular matrix restoration.
- MenSC-EVs show potential as a cell-free therapy for osteoarthritis or cartilage repair, with no significant impact on chondrocyte proliferation, migration, or motility observed.