Maternal immune activation perturbs intestinal niche through microbial glycerophospholipids and drives offspring behavioral abnormalities - PubMed
5 hours ago
- #gut-brain axis
- #maternal immune activation
- #neuroinflammation
- Maternal immune activation (MIA) in mice, induced by Toxoplasma gondii antigen, causes gut dysbiosis with increased Firmicutes and Actinobacteria.
- This dysbiosis disrupts intestinal barrier, increases inflammation (elevated M1 macrophages and IL-6), and raises glycerophospholipid OMPC levels, leading to placental and fetal neuroinflammation and offspring behavioral issues.
- Mechanistically, OMPC binds macrophage Tnfrsf25, activating JAK1/STAT3/IL-6 signaling, which drives the neurodevelopmental deficits.
- Maternal supplementation with probiotic Lactobacillus rhamnosus GG restores gut-immune balance, reduces inflammation, and rescues offspring behavioral abnormalities.