Halofuginone is a Molecular Glue Degrader of Integrin β4 - PubMed
3 hours ago
- #Molecular Glue Degrader
- #Integrin β4
- #Cancer Therapy
- Halofuginone (HF) identified as a molecular glue degrader of Integrin β4 (ITGB4).
- Integrin β4 overexpression linked to aggressive tumor phenotypes and poor prognosis.
- HF promotes degradation of Integrin β4 via the CRL4BWDR18 E3 ubiquitin ligase complex.
- HF administration disrupts tumor cell progression both in vitro and in vivo.
- Natural product screening proves useful for discovering molecular glue degraders.
- Provides a novel therapeutic strategy for targeting oncogenic transmembrane proteins.