Harnessing semen-derived exosomes for noninvasive fundus drug delivery: A paradigm for exosome-based ocular fundus therapeutics - PubMed
4 hours ago
- #retinoblastoma-treatment
- #exosome-drug-delivery
- #ocular-therapeutics
- Semen-derived exosomes (SEVs) effectively penetrate ocular barriers for noninvasive posterior ocular drug delivery.
- SEVs use epidermal growth factor to reversibly disrupt tight junctions, reaching the posterior segment via corneal and conjunctival routes.
- FA-SEVs@CMG eye drops combine FA-modified SEVs with a CMG nanozyme system to target retinoblastoma cells.
- The CMG nanozyme induces oxidative stress, disrupts autophagy-apoptosis balance, and triggers cancer cell self-destruction.
- In vivo studies show FA-SEVs@CMG inhibits retinoblastoma growth while preserving retinal function.