Multi-omics analysis reveals Yishen Qutong formula promotes ferroptosis in Lewis lung cancer associated with Keap1/Nrf2/Nqo1 pathway modulation - PubMed
3 days ago
- #Lung Cancer
- #Ferroptosis
- #Traditional Chinese Medicine
- Yishen Qutong Formula (YSQTF) is a traditional Chinese medicine effective in cancer pain treatment, with unclear anti-tumor mechanisms.
- Study aims to identify YSQTF's main components, targets, and mechanisms in Lewis lung cancer treatment.
- 39 compounds identified in YSQTF serum; 550 potential target genes predicted.
- YSQTF dose-dependently upregulates Keap1 and suppresses Nrf2 and Nqo1 in Lewis cells, promoting ferroptosis.
- Ferroptosis evidenced by increased iron, MDA, 4-HNE, ROS, and decreased GSH, GSSG, GSH/GSSG ratios.
- 3-hydroxycinnamic acid in YSQTF may regulate Keap1 expression.
- YSQTF's anti-tumor effect linked to Keap1/Nrf2/Nqo1 pathway modulation and ferroptosis promotion.