Regulatory T Cells in Ovarian Cancer: Insights into Cancer Immunotherapy - PubMed
4 hours ago
- #Regulatory T Cells
- #Ovarian Cancer
- #Immunotherapy
- Ovarian cancer (OC) has a low five-year survival rate and creates an immunosuppressive tumor microenvironment (TME).
- Regulatory T cells (Tregs) play a central role in OC by promoting immune evasion, tumor progression, and metastasis.
- Recent studies focus on Tregs' activation mechanisms and functional states in various diseases, but their role in OC needs further exploration.
- This review highlights Tregs' heterogeneity and functions in the TME, including immune tolerance, metabolic reprogramming, and microenvironment remodeling.
- The review aims to provide insights for precise immunotherapy strategies targeting Tregs in OC.