The impact of nutritional, environmental, and lifestyle factors on neurological disorders: therapeutic implications and mechanistic insights - PubMed

4 hours ago

Neurological disorders such as Alzheimer's, Parkinson's, and multiple sclerosis are influenced by genetic and modifiable risk factors.
Nutrition, environment, and lifestyle significantly impact disease development, progression, and treatment response.
Key nutrients like vitamins, minerals, omega-3 fatty acids, and polyphenols affect neuroinflammation, oxidative stress, and neurotransmitter function.
Dietary patterns such as Mediterranean and ketogenic diets provide protective benefits against neurological disorders.
Environmental neurotoxicants like air pollution, heavy metals, and pesticides contribute to neurodegeneration through oxidative damage and epigenetic changes.
Lifestyle factors including physical activity, sleep, stress, and substance use influence brain plasticity and neurogenesis.
Common pathways like oxidative stress, inflammation, and mitochondrial dysfunction link these factors to neurological diseases.
Emerging therapies integrate personalized nutrition, lifestyle changes, and environmental risk mitigation with traditional treatments.
Public health efforts aim to reduce neurotoxic exposure and promote healthy habits for brain health.
Future research is needed to enhance precision neurology and preventive strategies.

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