Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration - PubMed
3 hours ago
- #Autophagy
- #RGS19
- #Renal fibrosis
- Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.
- RGS19 is identified as a key fibrosis-related gene linked to impaired autophagy and immune activation in chronic kidney disease (CKD).
- Elevated RGS19 expression in fibrotic kidneys correlates with increased CD8+ T cell infiltration.
- Knockdown of RGS19 enhances autophagic flux by reducing p62 accumulation, suppressing mTOR activity, and restoring LC3B-II levels.
- RGS19 inhibition reduces secretion of T cell chemoattractants CXCL9 and CXCL10.
- RDYH58 nanoparticle-mediated delivery of RGS19 siRNA effectively reduces collagen deposition and immune cell infiltration in murine models.
- RGS19 is a potential therapeutic target for CKD due to its role in linking autophagy dysfunction with immune activation.