Plasma tau-species positive neuron-derived extracellular vesicles in progressive supranuclear palsy - PubMed
3 days ago
- #biomarkers
- #tau-species
- #progressive supranuclear palsy
- Plasma neuron-derived extracellular vesicles (NDEVs) containing tau species show promise as biomarkers for progressive supranuclear palsy (PSP).
- Study involved 188 participants across discovery and validation cohorts, comparing PSP, Parkinson's disease (PD), and healthy controls (HCs).
- Higher concentrations of tau, 4R tau, ptau181, ptau217, and ptau396-containing NDEVs were found in PSP patients compared to HCs and PD patients.
- An integrated biomarker model achieved high accuracy (AUC > 0.96) in distinguishing PSP from HCs and PD, including early-stage PSP.
- Findings suggest potential for early diagnosis and differentiation of PSP from PD, warranting further large-scale and longitudinal studies.