KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation - PubMed
8 hours ago
- #cementum-regeneration
- #glycolysis
- #periodontitis
- Periodontitis leads to irreversible tooth loss due to cementum deterioration.
- Cementum regeneration is crucial for periodontal and potential bone regeneration.
- KDM6B promotes cementoblast mineralization and formation.
- KDM6B regulates glycometabolic reprogramming during cementoblast mineralization.
- PDK1, a glycolysis enzyme, is a direct target of KDM6B.
- KDM6B-Pdk1 axis enhances lactate production, driving ZEB2 lactylation.
- ZEB2 lactylation promotes cementoblast mineralization.
- Sodium lactate supplementation restores mineralization impaired by KDM6B suppression.
- The KDM6B-Pdk1-ZEB2 lactylation axis is essential for cementogenesis.