Single-cell spatial transcriptomic analysis of human skin anatomy - PubMed
4 hours ago
- #single-cell analysis
- #skin anatomy
- #spatial transcriptomics
- Single-cell spatial transcriptomic analysis of human skin anatomy.
- Construction of an organ-wide single-cell spatial atlas of ~1.2 million cells from normal adult human skin.
- Identification of 45 cell types across 15 anatomic sites.
- Discovery of site-specific stereotypic cell-type composition and organization into ten multicellular neighborhoods.
- Highlighting a perivascular neighborhood reminiscent of skin-associated lymphoid tissue.
- Role of tumor necrosis factor in maintaining CCL19+ perivascular fibroblasts.
- Pan-disease immune alterations found in the perivascular neighborhood in skin disease.
- Multicellular neighborhoods underlie the skin's multiscale molecular to macroanatomic organization.