Associations of C-reactive protein, triglyceride-glucose index, and the C-reactive protein-triglyceride glucose index with multistate trajectories in the cardiovascular-renal-diabetes cluster - PubMed
4 hours ago
- #multimorbidity risk
- #CRP-TyG index
- #cardiovascular-renal-diabetes cluster
- The study investigated associations of CRP, TyG index, and their composite CTI with trajectories in the cardiovascular-renal-diabetes cluster.
- CTI consistently showed higher risks for CAD, T2DM, CKD, and multimorbidity, outperforming individual CRP and TyG.
- CTI exhibited trajectory-specific heterogeneity with nonlinear associations in most baseline-to-disease transitions.
- Participants with both high CRP and high TyG had the greatest risks across all outcomes.
- CTI integrates metabolic and inflammatory signals, offering clinical utility for refined risk stratification and prevention strategies.