Dual targeting of NCF1 and NLRP3 by roburic acid orchestrates redox homeostasis and inhibits macrophage death in septic lung injury - PubMed
3 hours ago
- #macrophage
- #inflammation
- #sepsis
- Roburic acid (RBA), delivered via nanoparticles (RBA-NPs), effectively attenuates septic acute lung injury (ALI) and improves survival in mouse models.
- RBA directly binds to NLRP3's NACHT domain, inhibiting inflammasome assembly and pyroptosis in macrophages.
- RBA also targets NCF1, suppressing NADPH oxidase 2 assembly, which restores redox balance and reduces ferroptosis caused by lipid peroxidation.