Adverse Childhood Experiences and Treatment-Resistant Depression - PubMed
7 hours ago
- #childhood trauma
- #mental health
- #depression
- Adverse Childhood Experiences (ACEs) are significant risk factors for major depressive disorder (MDD) and treatment-resistant depression (TRD).
- A study using Swedish Twin Registry data found that each additional ACE exposure increased the odds of TRD by 1.69 times.
- Physical neglect and sexual abuse showed the strongest associations with TRD, with odds ratios of 5.73 and 5.01, respectively.
- The study highlights the importance of preventing ACEs and considering ACE history in clinical assessments to identify individuals at higher risk for TRD.