Downregulation of Cathepsin B expression alleviates periodontitis by reducing mitochondrial reactive oxygen species production and NOD-, LRR-, and pyrin domain-containing 3 -mediated pyroptosis - PubM
4 hours ago
- #pyroptosis
- #Cathepsin B
- #periodontitis
- Downregulation of Cathepsin B (CTSB) alleviates periodontitis by reducing mitochondrial reactive oxygen species (ROS) production and NLRP3-mediated pyroptosis.
- Periodontitis is a common oral inflammatory disease where NLRP3-mediated pyroptosis plays a key role in its pathogenesis.
- CTSB, a lysosomal cysteine protease, is linked to programmed cell death and was investigated for its role in periodontitis via the NLRP3 pathway.
- In vivo and in vitro experiments showed that CTSB downregulation reduced alveolar bone resorption, macrophage infiltration, and inflammatory cytokine levels.
- CTSB inhibition also decreased mitochondrial and intracellular ROS levels, suggesting a mechanism involving ROS-induced NLRP3 activation.
- The study identifies a novel mechanistic axis (CTSB-mitochondrial ROS-NLRP3) in periodontitis, offering a potential therapeutic target.