A CD138+ tumor-associated macrophage-Siglec-F+ neutrophil feedforward loop promotes immune evasion in pancreatic cancer - PubMed
a day ago
- #Pancreatic Cancer
- #Immune Evasion
- #Immunotherapy
- Identifies CD138+ tumor-associated macrophages (TAMs) as key players in immune evasion in pancreatic ductal adenocarcinoma (PDAC).
- CD138+ TAMs expand in PDAC patients and mouse models, driven by IL-34-syndecan-1 and PGE2-EP2 signaling.
- These TAMs form a feedforward loop with immunosuppressive Siglec-F+ neutrophils, promoting immune escape and disease progression.
- Targeting CD138+ TAMs with anti-IL-34 neutralizing antibodies, especially combined with anti-PD-1, suppresses PDAC progression.
- Proposes a therapeutic strategy combining IL-34-syndecan-1 signaling blockade with anti-PD-1 immunotherapy for PDAC treatment.