Targeting a Shared Mitophagy Regulator: The SIRT1-FOXO3-DEPP1 Axis Underpins the Dual Bone and Brain Benefits of Total Flavonoids from Drynaria fortunei - PubMed
3 hours ago
- #depression
- #osteoporosis
- #mitophagy
- Postmenopausal osteoporosis and depression often co-occur, but a single treatment for both is lacking.
- Estrogen loss triggers oxidative stress, mitochondrial damage, and dysregulated autophagy, harming bone and brain health.
- Total flavonoids from Drynaria fortunei (TFDF) activate SIRT1, supporting autophagy and mitochondrial health.
- TFDF improved bone density, structure, and depression-like behaviors in menopausal and chronic stress model mice.
- TFDF modulated SIRT1-FOXO3-DEPP1 signaling, normalizing autophagic recycling and mitochondrial function in bone and brain.
- SIRT1 activity is necessary for TFDF's benefits, as shown in cellular models.
- TFDF offers a single, mechanism-based strategy for both skeletal deterioration and depressive symptoms postmenopause.