CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis - PubMed
6 days ago
- #cGAS-STING
- #mitochondria
- #ferroptosis
- Ferroptosis is a regulated cell death type marked by lipid peroxide accumulation damaging cell membranes.
- Mitochondrial swelling and dysfunction are key features of ferroptosis, with unclear causes and consequences.
- Mitochondrial permeability transition pore (mPTP) opening is crucial for mitochondrial swelling and ferroptosis activation.
- Oxidized mitochondrial DNAs (mtDNAs) are released through mPTP during ferroptosis.
- Oxidized mtDNAs activate the cGAS-STING pathway, promoting ferroptosis via ferrotinophagy activation.
- Inhibition of mtDNA-repair increases cellular sensitivity to ferroptosis and synergizes with ferroptosis inducers in tumor suppression.
- The study elucidates mPTP's role in ferroptosis by releasing mtDNAs as signaling messengers.