Determination of the effects of Herpes simplex glycoprotein B on epigenetic alterations in in vitro models of Alzheimer's disease - PubMed
7 hours ago
- #Alzheimer's disease
- #Epigenetics
- #HSV-1
- Epigenetic dysregulation is a key mechanism in Alzheimer's disease (AD) development and progression.
- Herpes simplex virus type 1 (HSV-1) infection may accelerate neurodegeneration through epigenetic modifications.
- Glycoprotein B (HSV-gB) of HSV-1 influences host-virus interactions affecting neuronal gene regulation.
- The study investigated HSV-gB's role in AD-related epigenetic alterations using in vitro neuronal AD models.
- Two AD models were used: a differentiation-based aging model and an amyloid aggregation model.
- HSV-gB exposure induced global DNA hypomethylation and histone hypoacetylation in the aging model.
- The amyloid model showed DNA hypermethylation and histone hyperacetylation, indicating distinct epigenetic profiles.
- HSV-gB contributes to AD-related epigenetic dysregulation, potentially through HDAC-mediated chromatin remodeling.
- The findings suggest viral factors may modulate AD-associated epigenetic pathways.