Whole-Blood vs Component Therapy in Adult Trauma: An Updated Systematic Review and Meta-Analysis - PubMed
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- #meta-analysis
- #trauma
- Hemorrhage is the leading preventable cause of trauma-related death.
- Whole-blood transfusion is associated with reduced 24-hour mortality compared to component therapy in civilian trauma patients (OR, 0.73; 95% CI, 0.57-0.93).
- No mortality benefit was observed in military settings (OR, 0.99; 95% CI, 0.58-1.70).
- Civilians also showed reduced 30-day mortality and lower transfusion requirements with whole-blood therapy.
- The study highlights substantial heterogeneity, suggesting benefits vary across settings.
- Findings support selective implementation of whole-blood transfusion protocols in civilian trauma centers.