Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure - PubMed
4 hours ago
- #gene therapy
- #heart failure
- #cardiac dysfunction
- BacNav gene therapy regulates sodium/calcium homeostasis to treat chronic heart failure.
- The therapy enhances Na+ current and Ca2+ transient amplitude in cardiomyocytes, improving contractility.
- Demonstrated efficacy in vitro (neonatal rat heart tissues), ex vivo (adult mouse CMs), and in silico (rabbit CMs).
- AAV9-mediated BacNav therapy rescues contractile deficits and prevents arrhythmias in a mouse model of heart failure.
- Long-term systemic delivery of AAV9-BacNav is safe in mice.
- BacNav gene therapy shows translational promise for treating electrical and contractile dysfunction in heart failure.