Orosomucoid 2 promotes colorectal cancer liver metastasis by suppressing natural killer cell-mediated antitumor immunity by remodeling the serine and one-carbon metabolism pathway - PubMed
8 hours ago
- #Colorectal cancer
- #NK cells
- #Liver metastasis
- Orosomucoid 2 (ORM2) promotes colorectal cancer liver metastasis by suppressing natural killer (NK) cell-mediated antitumor immunity.
- The mechanism involves remodeling the serine and one-carbon metabolism pathway.
- The study was conducted with ethical approval from FUSCC (050432-4-2108) and animal experiments approved by IACUC (No. FUSCC-IACUC-2024221).
- The authors declare no competing interests.
- Key references include studies on cancer metastasis mechanisms, liver metastases, and colorectal cancer management.